When a sensitive circuit must under no circumstances have too high a supply voltage applied, then some means of disconnecting the supply must be provided. One way to achieve this is to trigger a thyristor to blow a fuse. A less destructive alternative possibility is to use a MOSFET to disconnect the supply.An overvoltage protection IC, the LTC1696 from Linear Technology (www.linear-tech.com), has recently become available, which is suitable for triggering and driving such a device.
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